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US researchers have uncovered reasons why the Mediterranean diet, with its high intake of oleic acid-rich olive oil, seems to protect against breast cancer. They have also found evidence that oleic acid may have a future role in treatment. The findings are reported on Monday 10 January in Annals of Oncology. The researchers have demonstrated in a series of laboratory experiments on breast cancer cell lines that oleic acid dramatically cuts the levels of an oncogene called Her-2/neu (also known as erb B-2). High levels of Her-2/neu occur in over a fifth of breast cancer patients and are associated with highly aggressive tumours that have a poor prognosis. Not only did oleic acid suppress over-expression of the gene, other tests on the cell lines showed that it also boosted the effectiveness of trastuzumab (Herceptin), the monoclonal antibody treatment that targets the Her-2/neu gene and has helped to prolong the lives of many breast cancer patients. Lead researcher, Dr Javier Menendez, assistant professor at the Northwestern University Feinberg School of Medicine in Chicago and a research scientist with the Evanston Northwestern Healthcare Research Institute, said: "Our findings underpin epidemiological studies that show that the Mediterranean diet has significant protective effects against cancer, heart disease and ageing."



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